Detection of mis-specified relationships in inbred and outbred pedigrees.
نویسندگان
چکیده
Genome screen data collected for linkage analysis can be used to detect pedigree errors. We have developed methods applicable to a broad range of relationships. We discuss applications of our methods to data on asthma, in which we detect a number of likely mis-specified relative pairs. We propose a graphical method for error detection in complex inbred pedigrees, with application to the Hutterites.
منابع مشابه
Inference on Pedigree Structure from Genome Screen Data
The problem of error detection in general inbred and outbred pedigrees on the basis of genome screen data is considered. We develop a novel characterization of pairwise relationships, which is extended to k-wise relationships. Given an arbitrary pedigree specifying the relationship among a set of k individuals, we show how to prune the pedigree so that no information on the genetic relationship...
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عنوان ژورنال:
- Genetic epidemiology
دوره 21 Suppl 1 شماره
صفحات -
تاریخ انتشار 2001